Metabolism of acetaminophen (paracetamol) in plants—two independent pathways result in the formation of a glutathione and a glucose conjugate | Environmental Science and Pollution Research
The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model | Theoretical Biology and Medical Modelling | Full Text
ACETAMINOPHEN-INDUCED HEPATOTOXICITY | Drug Metabolism & Disposition
Conjugation With Glutathione and Mercapturic Acid Formation - Biotransformation of Drugs
Frontiers | Liquid Chromatography-Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S-Transferases
mednotes on X: "Paracetamol metabolism: 3 pathways Occurs in liver 1️⃣ 55% removed by glucuronic acid conjugation 2️⃣ 30% removed by sulphate conjugation 3️⃣ 15% turned into hepatotoxic metabolite NAPQI by cytochrome
Disposition of Glutathione Conjugates in Rats by a Novel Glutamic Acid Pathway: Characterization of Unique Peptide Conjugates by Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/NMR | Journal of Pharmacology and Experimental Therapeutics
University of Iowa Pathology on X: "GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. ❓How does ethanol interfere with acetaminophen metabolism?
16 Phase II reactions Conjugation with GSH paracetamol - YouTube
Glutathione conjugation - Metabolic Activation - European Medical
Metabolism of Paracetamol (Acetaminophen), Acetanilide and Phenacetin | Medicinal Chemistry | PharmaXChange.info
Molecular Modelling Analysis of the Metabolism of Paracetamol
Paracetamol - Metabolic Activation - European Medical
SOLVED: Question 1 (a) Briefly discuss the importance of glutathione in cell protection and relate this to its amino acid composition. (marks) (b) Outline how glutathione is involved in the detoxification of